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In podcast 67, Dr. Dimitre will cover the diagnostic approach to late-onset hypogonadism also known as andropause.

Late-onset hypogonadism (LOH),  causes a gradual yearly decrease in testosterone levels of 1 to 2% in men over the age of 40. While this condition is commonly known as Andropause there is no cessation of hormone production. However, just like menopause, this change in hormone levels can lead to a significant reduction in the quality of life of patients. 

Late-onset hypogonadism is a disease of both the testicles (primary hypogonadism) and the pituitary (secondary hypogonadism). It has a strong association with ageing and obesity. The latter being tied to insulin resistance and its effect on testosterone levels in the blood.

Most common symptoms are a noted decrease in libido, erectile function and muscle mass. There is also an association with low bone mineral density and mood issues. 

Clinicians should always rule out other causes for testosterone deficiency such as Klinefelter's Syndrome, hemochromatosis, and pituitary adenoma.

Posted on 21/06/2020 by Dr. Dimitre

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